Updated on March 13, 2025.
You may already be intimately familiar with the trial-and-error process involved in finding medications that help relieve your fibromyalgia symptoms. There are dozens of medicines you could try. Three are approved by the United States Food & Drug Administration (FDA) specifically for the treatment of fibromyalgia. They are:
- Duloxetine (Cymbalta), an antidepressant
- Pregabalin (Lyrica), a nerve pain medication
- Milnacipran (Savella)
Other drugs are used by healthcare providers (HCP) because they can help ease symptoms, but aren’t FDA-approved to treat fibromyalgia. These are called “off-label” medications.
It’s important to take a strategic approach by working closely with a healthcare provider (HCP) so you can monitor, modify, and fine-tune your fibromyalgia treatment program. Here are some of the medications they may prescribe to address some of the issues related to fibromyalgia.
Fibromyalgia pain
Several classes of medications may reduce fibromyalgia pain, including over-the-counter (OTC) pain relievers like acetaminophen, aspirin, and ibuprofen. If OTC products don't provide relief, prescription antidepressants and anticonvulsants may help. These include:
- Duloxetine (Cymbalta)
- Pregabalin (Lyrica)
- Gabapentin (Neuraptine), an anticonvulsant
Fibromyalgia sleep problems
Pain medications like pregabalin and gabapentin may also help with sleep problems, but not always. If you're having trouble sleeping, ask your HCP about adjusting your current fibromyalgia drug regime. You can also ask about the risks and benefits of adding an OTC sleep aid or a stronger prescription sleep aid such as a muscle relaxant or central nervous system depressant.
Medicines your HCP may prescribe to help with sleep issues include:
- Amitriptyline (Elavil), an antidepressant
- Diphenhydramine (Benadryl), an antihistamine that can make you sleepy
- Melatonin, a version of a naturally occurring hormone that plays a role in sleep
Fibromyalgia anxiety and depression
Anxiety and depression often accompany fibromyalgia. There are several classes of medications that may help with depression and pain, such as tricyclic antidepressants, serotonin and norepinephrine reuptake inhibitors (SNRIs), and selective serotonin reuptake inhibitors (SSRIs). Studies show that these medications can help with major depressive disorder, which may manifest in fibromyalgia patients as symptoms such as chronic fatigue, tiredness, and decreased energy. Prescription options include:
- Duloxetine (Cymbalta)
- Milnacipran (Savella)
Ask your HCP which option might be best for your symptoms.
Combine medications with exercise for additional benefit
It might seem counterintuitive to go for a walk or hit the gym when you’re in pain, but some studies show that exercise can help improve physical function while alleviating pain, helping with depression and anxiety, and improving sleep quality.
Speak with your HCP about how developing an exercise regime can supplement your prescription plan and help treat your fibromyalgia for overall wellness.
