Symptoms of stage 4 squamous cell carcinoma usually begin with some kind of skin lesion or growth. Often, the tumors of squamous cell carcinoma look like a scaly red patch of skin that won't heal. These tumors are often crusty and raised, and they may cause sores or ulcers that last for several weeks. At stage 4, these tumors may be large, both in diameter and in depth. Stage 4 squamous cell carcinoma most commonly develops on areas of skin that are exposed to the sun (such as the face, neck, and arms) but can develop almost anywhere, including the mouth and anus. Lesions are also more likely to develop on skin that's already been damaged, either by a scar or by a chronic skin infection or ulcer.
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