Is it time to brace for a “tripledemic”—flu, COVID, and RSV?

Learn what to expect this year, and the best way to protect yourself from these infections.

close up of vaccination in arm

Updated on September 9, 2024.

Once summer gives way to fall, the air chills, indoor spaces get more crowded, and many people (parents, in particular) brace for a seemingly endless string of sore throats, headaches, and runny noses.

In the U.S., COVID cases are already on the rise as flu and RSV season are about to get underway. But as of 2023, there are vaccines to help protect people them from all three of these seasonal threats.

Vaccination rates go a long way in determining how cold and flu seasons play out. Getting vaccinated is the best way to protect yourself and others from getting sick or avoiding severe infections and related complications. But there are a few other ways experts can predict what’s to come. Here is what we know so far.

What Australia’s flu season means for U.S.

Flu season in the Southern Hemisphere starts in April and lasts until September, while it spans October to May in the Northern Hemisphere. So, flu season in Australia, South America, and Africa is ending just as it’s about to begin in the United States. U.S. health officials monitor what happens in the southern hemisphere to help predict what’s in store for the northern hemisphere. In other words, if these countries just had a bad flu season, chances are we’re next.

What did we learn this year? Some notable takeaways:

  • Chile experienced very high levels of flu activity. Ecuador and Uruguay also saw high levels of severe flu-related disease, including very high levels of flu-related hospitalizations.
  • Most African countries have remained at low and moderate levels of influenza detections during the 2024 season.
  • Australia’s flu season peaked at the end of June—about two weeks later than last year. But it was the worst season on record since 2019, with a 10 percent increase in flu cases compared to the year before.

How COVID and RSV may complicate flu season

In 2023, more than 916,300 people in the United States were hospitalized with COVID and more than 75,500 people died from the disease. The virus that causes COVID is always changing. Meanwhile, people’s immunity to the disease declines over time. The best way to restore that protection is to get an updated 2024-2025 COVID vaccine, which protects against the variants causing most infections right now. The shot can also help reduce the odds of getting Long COVID.

Ongoing wastewater surveillance shows that COVID activity is currently high or very high in many states. Since children across the country have returned to the classroom, the virus could have more opportunity to spread.

And just as flu season gets underway, there is a third virus to consider: RSV. Respiratory syncytial virus (RSV) also tends to spread in the fall and winter months. Anyone can get it and most kids are infected by the age of 2.

Like flu, most people with RSV recover within a couple weeks. But for some people, these infections can be more serious and lead to complications—or even death.

Children and the elderly are especially vulnerable to RSV-related complications. Among children younger than 5 years old, the virus accounts for 58,000 to 80,000 hospitalizations in the U.S. every year. Among adults ages 65 and older, RSV leads to roughly 60,000 to 160,000 hospitalizations and between 6,000 and 10,000 deaths, according to the Centers for Disease Control and Prevention (CDC).

Which vaccines to get—and when

The good news: There are vaccines to help protect against the flu, COVID—and now RSV.

Flu: The CDC recommends that nearly everyone aged 6-months or older receive a flu vaccine each year. September and October are the best months to get vaccinated against the flu. Ideally, everyone should get their shot by the end of October. But it’s never too late.

And for people older than 65, high-dose flu vaccines are recommended. These high-dose shots can help older people develop a stronger immune response against the flu.

Getting the flu vaccine doesn’t guarantee that you won’t get the flu. But in seasons when the vaccine is well-matched to most circulating influenza viruses, getting a flu shot may decrease the risk of needing medical care for the flu by 40 percent to 60 percent. And the more people who vaccinate, the better. The percentage of people who get the vaccine is far more important to public health than its efficacy.

For example, a flu vaccine that’s only 20 percent effective could still save nearly 62,000 lives if 43 percent of the population got one, a 2018 study published in Proceedings of the National Academy of Sciences found. Boost that vaccination rate to 50 percent of the population, and nearly 8,500 additional flu deaths are avoided.

COVID: Everyone ages 6 months and older should receive the updated 2024-2025 COVID-19 vaccine.

You can get your flu shot and a COVID booster at the same time. It’s both safe and effective. The CDC also says that side effects are about the same whether a vaccine is given alone or at the same time as other vaccines. Tip: If you tend to get a sore arm or muscle, you can receive your shots in different arms. If you get them in the same arm, the two injections should be spaced at least one inch apart.

RSV: For the first time in 2023, the CDC recommended three new vaccines, which offer protection against RSV.

  1. Arexvy: This is the world’s first RSV vaccine. It is a protein subunit vaccine made by GSK. A protein subunit vaccine contains protein fragments—not live, weakened forms of the virus.
  2. Abrysvo: This vaccine is similar to Arexvy, but developed by Pfizer.
  3. mRESVIA: This is an mRNA vaccine made by Moderna. This type of vaccine works by using mRNA to deliver a piece of genetic material that carries instructions for making the protein that a virus uses to infect cells. This triggers an immune response in the body.

Who should be vaccinated?

  • Everyone ages 75 and older
  • Adults ages 60 to 74 at increased risk of severe RSV
  • Pregnant people between 32 and 36 weeks of pregnancy

The CDC also recommends nirsevimab (Beyfortus) to protect babies and some young children from RSV. This is not a vaccine. It is a monoclonal antibody made by Sanofi and AztraZeneca. Monoclonal antibodies are lab-made proteins that mimic the antibodies made by the body naturally. Some babies may not need this shot if their mother received the RSV vaccine at least 2 weeks before they were born. If not, one dose is given at the following ages:

  • Babies born between October and March should get 1 dose by the time they are 1 week old.
  • Babies born between April and September should get 1 dose before the start of their first RSV season (usually October).
  • Some babies who are at high risk for serious illness from RSV may need another dose at the start of their second RSV season.
Article sources open article sources

Centers for Disease Control and Prevention. CDC Recommends Updated COVID-19 Vaccine for Fall/Winter Virus Season. Sep 12, 2023.
U.S. Food and Drug Administration. FDA Takes Action on Updated mRNA COVID-19 Vaccines to Better Protect Against Currently Circulating Variants. Sep 22, 2023.
Centers for Disease Control and Prevention. 2022-2023 U.S. Flu Season: Preliminary In-Season Burden Estimates. Oct 28, 2022.
Centers for Disease Control and Prevention. Weekly U.S. Influenza Surveillance Report. Oct 28, 2022.
Centers for Disease Control and Prevention. COVID Data Tracker Weekly Review. Oct 28, 2022.
Centers for Disease Control and Prevention. COVID Data Tracker. Accessed Nov 2, 2022.
Kevin Messacar, Rachel E Baker, Sang Woo Park, et al. Preparing for uncertainty: endemic paediatric viral illnesses after COVID-19 pandemic disruption. The Lancet. Jul 14, 2022.
Centers for Disease Control and Prevention. Respiratory Syncytial Virus Infection (RSV). Oct 28, 2022.
Australian Department of Health and Aged Care. Australian Influenza Surveillance Report and Activity Updates, Sep 16, 2022.
Centers for Disease Control and Prevention. Frequently Asked Influenza (Flu) Questions: 2021-2022 Season. May 26, 2022.
Centers for Disease Control and Prevention. “Weekly U.S. Influenza Surveillance Report.” Nov 6, 2021.
Centers for Disease Control and Prevention. “Weekly National Flu Vaccination Dashboard.” Nov 3, 2021.
Centers for Disease Control and Prevention. “2020-2021 Flu Season Summary.” Updated July 22, 2021.
Centers for Disease Control and Prevention. “Frequently Asked Influenza (Flu) Questions: 2021-2022 Season.” Last reviewed Sep 1, 2021.
Centers for Disease Control and Prevention. “CDC COVID Data Tracker.” Sep 14, 2021.
Associated Press. “Crowded stadiums, pandemic create combustible mix this fall.” Sep 11, 2021.
Deloitte. “Executives share their plans for returning to the workplace.” Accessed Sep 13, 2021.
The New York Times. “Reopening Plans for the 100 Biggest School Districts Are Changing Fast.” Aug 13, 2021.
Statista. “Year over year retail foot traffic change during the coronavirus (COVID-19) outbreak in the United States in 2020 and 2021, by week.” Apr 2021.
CNBC. “Health experts are anxious to prevent a ‘catastrophic’ winter flu season.” July 7, 2021.
Krauland MG, Galloway DD, Raviotta JM et al. Agent-based Investigation of the Impact of Low Rates of Influenza on Next Season Influenza Infections. medRxiv 2021.08.18.21262185.
Centers for Disease Control and Prevention. “Disease Burden of Influenza.” Last reviewed June 11, 2021.
Lazarus R, Baos S, Cappel-Porter H et al. The safety and immunogenicity of concomitant administration of COVID-19 vaccines (ChAdOx1 or BNT162b2) with seasonal influenza vaccines in adults: a phase IV, multicentre randomised controlled trial with blinding (ComFluCOV). The Lancet preprint.
Lee K, Jalal H, Raviotta JM et al. Predicting the impact of low influenza activity in 2020 on population immunity and future influenza season in the United States. medRxiv 2021.08.29.21262803.
Centers for Disease Control and Prevention. “Flu Vaccination Coverage, United States, 2019–20 Influenza Season.” Oct 1, 2020.
Sah P, Medlock J, Fitzpatrick MC et al. Optimizing the impact of low-efficacy influenza vaccines. Proc Natl Acad Sci U S A. 2018;115(20):5151-5156.
Centers for Disease Control and Prevention. “Interim Clinical Considerations for Use of COVID-19 Vaccines Currently Approved or Authorized in the United States.” Last updated Aug 31, 2021.
Grohskopf LA, Alyanak E, Ferdinands JM et al. Prevention and Control of Seasonal Influenza with Vaccines: Recommendations of the Advisory Committee on Immunization Practices, United States, 2021–22 Influenza Season. MMWR Recomm Rep 2021;70(No. RR-5):1–28.

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