LAMOTRIGINE (la MOE tri jeen) prevents and controls seizures in people with epilepsy. It may also be used to treat bipolar disorder. It works by calming overactive nerves in your body.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

They need to know if you have any of these conditions: -Heart disease -History of irregular heartbeat -Immune system problems -Kidney disease -Liver disease -Low levels of folic acid in the blood -Lupus -Mental health condition -Suicidal thoughts, plans, or attempt by you or a family member -An unusual or allergic reaction to lamotrigine, other medications, foods, dyes, or preservatives -Pregnant or trying to get pregnant -Breastfeeding

Take this medication by mouth with a glass of water. Follow the directions on the prescription label. Do not chew these tablets. If this medication upsets your stomach, take it with food or milk. Take your doses at regular intervals. Do not take your medication more often than directed. A special MedGuide will be given to you by the pharmacist with each new prescription and refill. Be sure to read this information carefully each time. Talk to your care team about the use of this medication in children. While this medication may be prescribed for children as young as 2 years for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. NOTE: This medicine is only for you. Do not share this medicine with others.

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

-Atazanavir -Certain medications for irregular heartbeat -Certain medications for seizures, such as carbamazepine, phenobarbital, phenytoin, primidone, or valproic acid -Estrogen or progestin hormones -Lopinavir -Rifampin -Ritonavir

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

Visit your care team for regular checks on your progress. If you take this medication for seizures, wear a Medic Alert bracelet or necklace. Carry an identification card with information about your condition, medications, and care team. It is important to take this medication exactly as directed. When first starting treatment, your dose will need to be adjusted slowly. It may take weeks or months before your dose is stable. You should contact your care team if your seizures get worse or if you have any new types of seizures. Do not stop taking this medication unless instructed by your care team. Stopping your medication suddenly can increase your seizures or their severity. This medication may cause serious skin reactions. They can happen weeks to months after starting the medication. Contact your care team right away if you notice fevers or flu-like symptoms with a rash. The rash may be red or purple and then turn into blisters or peeling of the skin. You may also notice a red rash with swelling of the face, lips, or lymph nodes in your neck or under your arms. This medication may affect your coordination, reaction time, or judgment. Do not drive or operate machinery until you know how this medication affects you. Sit up or stand slowly to reduce the risk of dizzy or fainting spells. Drinking alcohol with this medication can increase the risk of these side effects. If you are taking this medication for bipolar disorder, it is important to report any changes in your mood to your care team. If your condition gets worse, you get mentally depressed, feel very hyperactive or manic, have difficulty sleeping, or have thoughts of hurting yourself or committing suicide, you need to get help from your care team right away. If you are a caregiver for someone taking this medication for bipolar disorder, you should also report these behavioral changes right away. The use of this medication may increase the chance of suicidal thoughts or actions. Pay special attention to how you are responding while on this medication. Your mouth may get dry. Chewing sugarless gum or sucking hard candy and drinking plenty of water may help. Contact your care team if the problem does not go away or is severe. If you become pregnant while using this medication, you may enroll in the North American Antiepileptic Drug Pregnancy Registry by calling 1-888-233-2334. This registry collects information about the safety of antiepileptic medication use during pregnancy. This medication may cause a decrease in folic acid. You should make sure that you get enough folic acid while you are taking this medication. Discuss the foods you eat and the vitamins you take with your care team.

Keep out of the reach of children and pets. Store at 25 degrees C (77 degrees F). Protect from light. Get rid of any unused medication after the expiration date. To get rid of medications that are no longer needed or have expired: -Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location. -If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put it in the trash, empty the medication out of the container. Mix the medication with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.