OMEPRAZOLE (oh ME pray zol) is used to treat heartburn, stomach ulcers, reflux disease, or other conditions that cause too much stomach acid. It works by reducing the amount of acid in the stomach. It belongs to a group of medications called PPIs.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

They need to know if you have any of these conditions: -Liver disease -Low levels of calcium, magnesium, or potassium in the blood -Lupus -An unusual or allergic reaction to omeprazole, other medications, foods, dyes, or preservatives -Pregnant or trying to get pregnant -Breastfeeding

Take this medication by mouth with a glass of water. Take it as directed on the label at the same time every day. Do not cut, crush, or chew this medication. Swallow the capsules whole. You may open the capsule and put the contents in 1 tablespoon of applesauce. Swallow the medication and applesauce right away. Do not chew the medication or applesauce. Take this medication before a meal. Keep taking it unless your care team tells you to stop. Talk to your care team about the use of this medication in children. While it may be prescribed for children as young as 2 years for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. NOTE: This medicine is only for you. Do not share this medicine with others.

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Do not take this medication with any of the following: -Atazanavir -Clopidogrel -Nelfinavir -Rilpivirine This medication may also interact with the following: -Antifungals, such as itraconazole, ketoconazole, voriconazole -Certain antivirals for HIV or hepatitis -Certain medications that treat or prevent blood clots, such as warfarin -Cilostazol -Citalopram -Cyclosporine -Dasatinib -Digoxin -Disulfiram -Diuretics -Erlotinib -Iron supplements -Medications for anxiety, panic, and sleep, such as diazepam -Medications for seizures, such as carbamazepine, phenobarbital, phenytoin -Methotrexate -Mycophenolate mofetil -Nilotinib -Rifampin -St. John's wort -Tacrolimus -Vitamin B12

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

Visit your care team for regular checks on your progress. It can take several days before your stomach pain gets better. Tell your care team if your symptoms do not start to get better or if they get worse. Do not treat diarrhea with over the counter products. Contact your care team if you have diarrhea that lasts more than 2 days or if it is severe and watery. You may need blood work while taking this medication. Using this medication for a long time may weaken your bones. The risk of bone fractures may be increased. Talk to your care team about your bone health. Using this medication for a long time may cause growths (polyps) in the stomach. They usually don't cause any symptoms. They are usually not cancerous. Contact your care team if you notice pain or tenderness when you press your stomach, have nausea, or see bloody or black, tar-like stools. This medication may cause a decrease in vitamin B12. You should make sure that you get enough vitamin B12 while you are taking this medication. Discuss the foods you eat and the vitamins you take with your care team.

Keep out of the reach of children and pets. Store between 15 and 30 degrees C (59 and 86 degrees F). Protect from light and moisture. Get rid of any unused medication after the expiration date. To get rid of medications that are no longer needed or expired: -Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location. -If you cannot return the medication, check the label or package insert to see if the medication should be thrown out in the garbage or flushed down the toilet. If you are not sure, ask your care team. If it is safe to put in the trash, empty the medication out of the container. Mix the medication with cat litter, dirt, coffee grounds, or other unwanted substance. Seal the mixture in a bag or container. Put it in the trash.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.